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The aim of this study was to analyze CSF of patients with ALS by 1H NMR in order to identify biomarkers in the early stage of the disease, and to evaluate the biochemical factors involved in this disease.

Ornithine Transcarbamylase Deficiency with Persistent Abnormality in Cerebral Glutamate Metabolism Napapon Sailasuta 1, Andrea L.

Deary 2, Joanna M.

Winter 1, Jelena Lukovic 1, Andrea Kassner 1,2 1Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Medical Imaging, University of Toronto, Toronto, Ontario, Canada In this study, we explored the potential of the swine brain for neurodevelopmental imaging by MRI characterization of structural and microstructural changes.

Results: Hypoperfusion was detected in parietal cortex and right angular gyrus when patients were compared to controls.

Carew 2,3, Sharon Usher 4, Michael Benatar 4,5, Xiaoping P.